Duke Nukem Advance isn't simply a port of the old PC version, instead, the developers have created a brand new adventure. Aliens have invaded the Earth, and it is Duke, working for the government, that will stop them. Most of the monsters you will be shooting are the same from the other games, such as the infamous evil pigs. But, Take 2 has added some more creatures: aliens that fire telepathic beams at you, and large bosses such as immense, 8-legged spiders.

The graphics are very well done for a Game Boy Advance game, with a very 3D appearance, although they tend to look a little grainy. The level design is somewhat impaired in some parts, but other areas look great. My favorite levels in all Duke Nukem games are the outdoor urban areas, shooting bad guys on the streets and taking out fire hydrants. Gameplay is still very one dimensional, because there is only one way to complete the level, collecting keys and hitting switches just like any other shooter game. I didn't find enough variety in some of the missions, although some parts are very cool and fun to play.

The game also has multiplayer for up to four players, but each player has to obtain the game's cartridge, and I haven't found anybody to test this mode with. I have heard from other reviewers that the multiplayer portion of the game is also very good. I would recommend this game to anybody looking for a good first person shooter on their Game Boy Advance.